Acute cell injury Manifestation by cell swelling Gray substance, big core Pale central chromatin Nuclear membrane and prominent nucleoli Chronic liver disease Hereditary metabolic disorders of the urea cycle Other types of cell damage It leads to a formation of cytoplasmic inclusion bodies A type of glial tumor Astro pilocytic astrocytoma When there is inflammation or marked Dilation of the ventricular system The rupture of the ependymal lining Occurs along with the proliferation of astrocytes Causing irregularities in ventricular system