Necrosis is always a pathological and disordered process The cells die caused by factors that lead to irreversible cell damage Hypoxia/ischemia/toxic chemical agents Biological agents/direct damage A harmful immune response Such as fungi, bacteria and viruses State of death Group of cells Loss of permeability Inflammatory response Coagulation is determined by the denaturation of most Cellular proteins Loss of nuclear contour Loss of nuclear basophilia